Expresión de búsqueda: DNA TOPOISOMERASE IV 
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Descriptor Inglés:   DNA Topoisomerase IV 
Descriptor Español:   Topoisomerasa de ADN IV 
Descriptor Portugués:   DNA Topoisomerase IV 
Sinónimos Inglés:   parC Protein
parE Protein  
Categoría:   D08.811.399.403.741.224
D12.776.097.256
Definición Inglés:   A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication. 
Nota Histórica Inglés:   2002; use DNA TOPOISOMERASE IV (NM) 1991-2001 
Calificadores Permitidos Inglés:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número del Registro:   36090 
Identificador Único:   D027101 

Ocurrencia en la BVS:
 

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